Insulin signaling and action in skeletal muscle: regulation by crosstalk with leptin and resistin signaling

骨骼肌中的胰岛素信号传导和作用：通过瘦素和抵抗素信号传导的串扰进行调节

• 批准号: 250186-2007
• 负责人: Sweeney, Gary
• 金额: $ 1.53万
• 依托单位: York University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=394681
• 关键词: Insulin; signaling; action; skeletal; muscle

Insulin is one of the most famous hormones known and has a widespread importance across a surprisingly large range of species. This is due to the fact that the mechanisms which insulin uses to control the function of cells has been very highly conserved throughout evolution. The work conducted by my research program focuses on how this ability of insulin to control cell function is regulated by other hormones, in this case leptin and resistin. Being able to identify these events at the cellular level will play an important role in providing the basic biological framework for future applied studies and is thus of widespread relevance to mammalian physiology.

胰岛素是已知的最著名的激素之一，在许多物种中具有广泛的重要性。这是因为胰岛素用于控制细胞功能的机制在整个进化过程中高度保守。我的研究项目所进行的工作主要集中在胰岛素控制细胞功能的能力如何受到其他激素的调节，在这种情况下，瘦素和Leptin。能够在细胞水平上识别这些事件将在为未来的应用研究提供基本生物学框架方面发挥重要作用，因此与哺乳动物生理学具有广泛的相关性。