Selective serotonin re-uptake inhibitors (SSRIs) and osteoporosis: Mechanisms and clinical consequences

选择性血清素再摄取抑制剂（SSRIs）通常用于治疗抑郁症。血清素并不是大脑所独有的，它也被身体的其他细胞所使用，包括骨细胞。在这个项目中，SSRIs对人破骨细胞和成骨细胞形成和功能的影响将在实验室进行研究。此外，将调查在社区样本中使用SSRI对女性和男性骨质流失和骨折风险的影响。这些研究将确定暴露于SSRIs是否会对骨骼健康产生不利影响。

Selective serotonin re-uptake inhibitors (SSRIs) are commonly used to treat depression. Serotonin is not unique to the brain but is also used by other cells in the body, including bone cells. In this project the influence of SSRIs on human osteoclast and osteoblast formation and function will be investigated in a laboratory. Additionally, the impact of SSRI use on bone loss and fracture risk in a community sample of women and men will be investigated. These studies will determine if exposure to SSRIs adversely impact bone health.