Shaken baby syndrome: characterization of a model and evaluation of novel pharmacological therapies

摇晃婴儿综合症是一种创伤性脑损伤，发生在2岁以下的婴儿身上。它会导致10%-40%的病例死亡，并导致幸存者的神经问题。没有治疗方法的存在，很大程度上是因为没有复制人类情况的具有良好特征的综合症模型。这项研究将全面描述我们新开发的摇晃婴儿综合征模型，并检验一种针对脑肿胀的新型干预策略的有效性。

Shaken baby syndrome is a form of traumatic brain injury in infants less than 2 years of age. It results in death in 10-40 % of cases, and neurological problems in survivors. No treatment exists largely because there is no well characterized model of the syndrome that replicates the human situation. This study will fully characterize our newly developed model of shaken baby syndrome and examine the effectiveness of a novel interventional strategy targeting brain swelling.