Signal integration of chimeric antigen receptors and the inhibitory Programmed cell death protein 1 receptor

T细胞通过整合来自激活和抑制表面受体的信息，识别并杀死感染细胞或癌细胞，并耐受健康组织。针对癌症而设计的激活受体作为治疗手段显示出巨大的希望，但它们对内源性抑制受体的敏感性尚不清楚。我们将使用强大的生化和显微镜技术来探究这个问题。研究结果将为设计更有效的抗癌疗法提供信息。

T cells recognise and kill infected or cancerous cells and tolerate healthy tissue by integrating information from activating and inhibitory surface receptors. Activating receptors engineered to target cancer show great promise as therapies but their sensitivity to endogenous inhibitory receptors, which cancers exploit, is unknown. We will use powerful biochemical and microscopy techniques to probe this question. The results will inform the design of more effective anti-cancer therapeutics.