Signal integration of chimeric antigen receptors and the inhibitory Programmed cell death protein 1 receptor

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T cells recognise and kill infected or cancerous cells and tolerate healthy tissue by integrating information from activating and inhibitory surface receptors. Activating receptors engineered to target cancer show great promise as therapies but their sensitivity to endogenous inhibitory receptors, which cancers exploit, is unknown. We will use powerful biochemical and microscopy techniques to probe this question. The results will inform the design of more effective anti-cancer therapeutics.