Simvastatin prevents dopaminergic neuronal injury in experimental PD models via activation of NF-kB and MMP 9 and 3

辛伐他汀通过激活 NF-kB 和 MMP 9 和 3 预防实验性 PD 模型中的多巴胺能神经元损伤

• 批准号: nhmrc : 514640
• 负责人: Qing Wang
• 金额: $ 5.86万
• 依托单位: University of Wollongong
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/simvastatin-prevents-dopaminergic-9-3/115673
• 关键词: Simvastatin; prevents; dopaminergic; neuronal; injury

Increasing evidence shows that neuroinflammation may account for dopamine neuron death in Parkinson’s disease (PD). This work aims to provide systematic picture of inflammatory response in PD, and explore anti-inflammatory mechanisms of simvastatin on the progression of PD. We expect that the results may provide a therapeutic strategy using simvastatin via different methods of administration in treating PD, and provide new information about the anti-inflammatory roles of simvastatin.

越来越多的证据表明，神经炎症可能是帕金森病(PD)中多巴胺神经元死亡的原因。本研究旨在提供帕金森病炎症反应的系统图景，并探讨辛伐他汀在帕金森病进展过程中的抗炎机制。我们期望这一结果可以为辛伐他汀通过不同给药方法治疗帕金森病提供一种治疗策略，并为辛伐他汀的抗炎作用提供新的信息。