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Simvastatin prevents dopaminergic neuronal injury in experimental PD models via activation of NF-kB and MMP 9 and 3

Simvastatin prevents dopaminergic neuronal injury in experimental PD models via activation of NF-kB and MMP 9 and 3
辛伐他汀通过激活 NF-kB 和 MMP 9 和 3 预防实验性 PD 模型中的多巴胺能神经元损伤
批准号：
nhmrc : 514640
负责人：
Qing Wang
金额：
$5.86万
依托单位：
University of Wollongong
依托单位国家：
澳大利亚
项目类别：
Early Career Fellowships
财政年份：
2008
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2008-01-01 至 2009-12-31
来源：
https://researchdata.edu.au/simvastatin-prevents-dopaminergic-9-3/115673
关键词：
Simvastatinpreventsdopaminergicneuronalinjury

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中文摘要
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英文摘要
Increasing evidence shows that neuroinflammation may account for dopamine neuron death in Parkinson’s disease (PD). This work aims to provide systematic picture of inflammatory response in PD, and explore anti-inflammatory mechanisms of simvastatin on the progression of PD. We expect that the results may provide a therapeutic strategy using simvastatin via different methods of administration in treating PD, and provide new information about the anti-inflammatory roles of simvastatin.
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Advancing Academic Success and Career Development for Talented, Low-Income Computer Science, Mathematics, and Engineering Majors
  • 批准号：
    2130267
  • 项目类别：
    Standard Grant
  • 资助金额：
    $150.0万
  • 财政年份：
    2021
  • 负责人：
    Qing Wang
  • 依托单位：
    Shepherd University
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