The spilt personality of glutamate transporters: the structural basis and physiological role of a dual function transporter/channel

谷氨酸转运蛋白的溢出特性：双功能转运蛋白/通道的结构基础和生理作用

• 批准号: nhmrc : GNT1164494
• 金额: $ 96.79万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/spilt-personality-glutamate-function-transporterchannel/1379355
• 关键词: spilt; personality; glutamate; transporters; structural

Membrane proteins are pumps that control the movement of nutrients, waste products and chemical messengers in and out of cells. These pumps break down in a wide range of diseases including neurological disorders and cancer. This project is focused on a unique type of transporter/channel hybrid protein that uses a ‘twisting elevator’ mechanism. We will uncover how they work and what goes wrong in disease. This information can then be used to develop new drugs to improve transporter function.

膜蛋白是控制营养物质、废物和化学信使进出细胞的泵。这些泵在包括神经系统疾病和癌症在内的多种疾病中发生故障。该项目的重点是一种独特的类型的转运蛋白/通道杂交蛋白，使用“扭转电梯”机制。我们将揭示它们是如何工作的，以及疾病中出现了什么问题。这些信息可以用于开发新的药物来改善转运蛋白的功能。