The spilt personality of glutamate transporters: the structural basis and physiological role of a dual function transporter/channel

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Membrane proteins are pumps that control the movement of nutrients, waste products and chemical messengers in and out of cells. These pumps break down in a wide range of diseases including neurological disorders and cancer. This project is focused on a unique type of transporter/channel hybrid protein that uses a ‘twisting elevator’ mechanism. We will uncover how they work and what goes wrong in disease. This information can then be used to develop new drugs to improve transporter function.