Star polymers as novel antimicrobial and immunomodulatory agents

星形聚合物作为新型抗菌剂和免疫调节剂

• 批准号: nhmrc : 1142472
• 负责人: A/Pr Justin Denholm
• 金额: $ 63.96万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/star-polymers-novel-immunomodulatory-agents/1319716
• 关键词: Star; polymers; novel; antimicrobial; immunomodulatory

The rise in antibiotic resistance in bacteria is considered as a major public health threat that is not being met by antibiotic research. This project will modify a novel star polymer that we have shown kills antibiotic resistant bacteria but does not induce resistance. The project will make and characterise new versions of the star polymer to produce antimicrobial materials that target and kill the multi-drug resistant bacteria that are a major cause of bacterial infections and death.

细菌中抗生素耐药性的上升被认为是抗生素研究所没有解决的主要公共卫生威胁。该项目将修改一种新的星星聚合物，我们已经证明它可以杀死抗生素耐药细菌，但不会诱导耐药性。该项目将制造和验证新版本的星星聚合物，以生产针对并杀死多重耐药细菌的抗菌材料，这些细菌是细菌感染和死亡的主要原因。