Statistical issues in the analysis of host-viral genetic associations

诸如HIV或肝炎B或C的病毒可以通过策略性突变逃避人类宿主免疫系统的检测，并因此逃避控制。该项目旨在开发统计方法，以便于确定这些战略突变的位置，并评估不同的人类宿主遗传特征的相对影响。这些结果的应用将有助于定制疫苗的设计和耐药性研究。

Viruses such as HIV or Hepatitis B or C may escape detection, and hence control, by the human host immune system through strategic mutations. This project aims to develop statistical methodologies which will facilitate determination of the locations of these strategic mutations and assess the relative impact of different human-host genetic characteristics. Application of the results should benefit the design of tailored vaccines and studies of drug resistance.