The role of sleep oscillations in temporal lobe organization

睡眠振荡在颞叶组织中的作用

• 批准号: 356071-2008
• 负责人: Hoffman, Kari
• 金额: $ 2.18万
• 依托单位: York University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=402852
• 关键词: role; sleep; oscillations; temporal; lobe

Even when we sleep, the brain is not at rest. On the contrary, during sleep, the brain is full of synchronized neural activity that takes the shape of slow oscillations. These oscillations have long been associated with helping memories to strengthen, or 'consolidate', yet the brain regions involved during slow waves and the processing they undergo is still unresolved. Neurons in the neocortex that were active during an experience 'reactivate' during these sleep oscillations, suggesting one way of strengthening a memory trace. Although this phenomenon was first seen in the rat hippocampus - a structure that helps in forming new memories, I went on to show that reactivation occurs as a synchronized process throughout large, separated regions of the neocortex. This was also the first demonstration of memory trace reactivation in primates, an important prerequisite if reactivation underlies the consolidation of memories in humans.

即使我们睡着了，大脑也没有休息。相反，在睡眠期间，大脑充满了同步的神经活动，这些活动以缓慢振荡的形式出现。这些振荡长期以来一直与帮助记忆加强或“巩固”有关，但慢波所涉及的大脑区域及其所经历的处理仍然没有解决。新皮层中的神经元在一次经历中被激活，在这些睡眠振荡中被“重新激活”，这表明了一种加强记忆痕迹的方式。虽然这种现象最早是在老鼠的海马体中发现的--海马体是一种有助于形成新记忆的结构，但我继续证明，重新激活是一个同步的过程，贯穿于新皮层的大而分离的区域。这也是灵长类动物记忆痕迹重新激活的第一次证明，如果重新激活是人类记忆巩固的基础，这是一个重要的先决条件。