STICs and STONes: A Randomised, Phase II, Double-Blind, Placebo-Controlled Trial of Aspirin in Chemoprevention of Ovarian Cancer in Women with BRCA1 and BRCA2 Mutations

STIC 和 STONE：阿司匹林化学预防 BRCA1 和 BRCA2 突变女性卵巢癌的随机、II 期、双盲、安慰剂对照试验

• 批准号: nhmrc : 1122290
• 负责人: A/Pr Alison Brand
• 金额: $ 44.66万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/stics-stones-randomised-brca2-mutations/946918
• 关键词: STICs; STONes; Randomised; Phase; II

Women with a BRCA1 or BRCA2 gene abnormality are at increased risk of ovary and fallopian tube (O&FT) cancers and often have their O&FTs removed to prevent cancer. Microscopic cancers are often seen at the time of surgery. Some studies suggest that aspirin might reduce O&FT cancer risk. This study will assign women to daily aspirin or placebo for 6-24 months before their preventive O&FT surgery. It will provide a better understanding of how O&FT cancers start and the influence aspirin may have.

BRCA 1或BRCA 2基因异常的女性患卵巢和输卵管（O&FT）癌的风险增加，并且经常切除O& FT以预防癌症。显微镜下的癌症经常在手术时看到。一些研究表明，阿司匹林可能会降低O&FT癌症的风险。这项研究将分配妇女在预防性O&FT手术前6-24个月每天服用阿司匹林或安慰剂。它将更好地了解O&FT癌症如何开始以及阿司匹林可能产生的影响。