Structural biology of malaria parasite invasion and antibodies-mediated inhibition

疟原虫入侵的结构生物学和抗体介导的抑制

• 批准号: nhmrc : 1196945
• 金额: $ 156.23万
• 依托单位国家: 澳大利亚
• 项目类别: Investigator Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://researchdata.edu.au/structural-biology-malaria-mediated-inhibition/1779216
• 关键词: Structural; biology; malaria; parasite; invasion

Malaria results in significant mortality but an effective vaccine does not yet exist. The Rh5-CyRPA-Ripr complex is essential for malaria parasite to invade erythrocytes and is the leading vaccine candidate. We aim to visualise the atomic details of the Rh5-CyRPA-Ripr complex during parasite invasion of erythrocytes and how antibodies neutralise this key protein complex. This information will advance knowledge on malaria parasite invasion, which will help to design an effective malaria vaccine.

疟疾导致大量死亡，但目前还没有有效的疫苗。Rh 5-CyRPA-Ripr复合物是疟原虫侵入红细胞所必需的，并且是领先的疫苗候选物。我们的目标是可视化Rh 5-CyRPA-Ripr复合物在寄生虫入侵红细胞过程中的原子细节，以及抗体如何中和这种关键蛋白质复合物。这些信息将推进有关疟原虫入侵的知识，这将有助于设计有效的疟疾疫苗。