Structural and functional characterisation of the oncogene P-Rex1

癌基因 P-Rex1 的结构和功能表征

• 批准号: nhmrc : 1128120
• 负责人: Dr Andrew Ellisdon
• 金额: $ 42.53万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structural-functional-characterisation-p-rex1/948145
• 关键词: Structural; functional; characterisation; oncogene; Rex1

The spread of cancer to other parts of the body (metastasis) is a major cause of mortality. The characterisation of proteins that regulate metastasis is therefore a priority. P-Rex1 plays a crucial role in promoting metastasis in breast and other cancers. We will determine the structural basis of P-Rex1 activity, and investigate how its dysregulation promotes aberrant cell growth. This study will provide the knowledge to build future drug development programs targeting P-Rex1 in cancer.

癌症扩散到身体其他部位（转移）是死亡的主要原因。因此，表征调节转移的蛋白质是优先事项。P-Rex 1在促进乳腺癌和其他癌症的转移中起着至关重要的作用。我们将确定P-Rex 1活性的结构基础，并研究其失调如何促进异常细胞生长。这项研究将为建立未来针对癌症P-Rex 1的药物开发计划提供知识。