A study of artemisinin combination therapy given at delivery to prevent postpartum malaria and to young infants to treat uncomplicated malaria

拟议的研究将调查疟疾地区孕妇分娩时一个疗程的联合抗疟疾治疗的预防价值。将调查将这种治疗转移到母乳和哺乳婴儿身上的情况，因为这可能保护婴儿免受疟疾的侵害，但也会引起与药物有关的副作用。这些数据将与一项针对疟疾婴儿的联合治疗研究一起使用，以优化这一弱势群体的剂量方案。

The proposed studies will investigate the preventive value of a course of combination antimalarial treatment at delivery in pregnant women in malarial areas. The transfer of this treatment into breast milk and to the suckling infant will be investigated since this may protect the infant against malaria but also cause drug-related side-effects. These data will be used, with a study of combination treatment in infants with malaria, to optimise dose regimens in this vulnerable group.