Delineating the developmental requirements for stem-like T cells

干细胞样CD8 T细胞对于维持长期系统性T细胞活性至关重要。然而，发展这些机制所需的信号仍然难以捉摸。该项目整合了多学科专业知识，尖端技术和高度创新的方法，旨在定义组织微环境提供的信号线索，这些信号线索控制干细胞样T细胞的发育和维持，从而决定系统免疫。该项目预计将产生关于基础免疫学和T细胞生物学的基础知识，通过提高澳大利亚基础免疫学研究的国际地位和促进新的商业机会，使学术，公共卫生和生物技术部门受益。

Stem-like CD8 T cells are critical for sustaining long-term systemic T cell activity. The signalling required for their development, however, remains elusive. Integrating multidisciplinary expertise, cutting-edge technology and highly innovative methods, this project aims to define the signalling cues provided by tissue microenvironment that control the development and maintenance of stem-like T cells, and thereby dictate systemic immunity. This project is expected to generate fundamental knowledge on basic immunology and T cell biology, which can benefit the academic, public health and biotechnology sectors by enhancing the international standing of Australian research on basic immunology and fostering new commercial opportunities.