Susceptibility of the basal layer of human epidermis to UVA oxidative damage due to pheomelanin and suboptimal DNA repair

人表皮基底层对褐黑素和次优 DNA 修复引起的 UVA 氧化损伤的敏感性

• 批准号: nhmrc : 1009021
• 负责人: A/Pr James Guy Lyons
• 金额: $ 37.3万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/susceptibility-basal-layer-dna-repair/109366
• 关键词: Susceptibility; basal; layer; human; epidermis

Australia has the highest incidence of skin cancer in the world. It is important to understand how sunlight causes skin cancer and the wavelengths involved in order to devise effective preventative and therapeutic strategies. Our proposal is that the cells in the skin that give rise to the most common forms of skin cancer, squamous cell carcinoma and basal cell carcinoma, are particularly vulnerable to UVA. We aim to study why this is the case and whether this vulnerability can be prevented.

澳大利亚是世界上皮肤癌发病率最高的国家。重要的是要了解阳光如何导致皮肤癌以及所涉及的波长，以便制定有效的预防和治疗策略。我们的建议是，皮肤中引起最常见形式的皮肤癌，鳞状细胞癌和基底细胞癌的细胞特别容易受到UVA的影响。我们的目标是研究为什么会出现这种情况，以及这种脆弱性是否可以预防。