Targeted disruption of lipoxygenase enzymes to prevent oxidative stress-mediated pathologies in the male germline

有针对性地破坏脂氧合酶以预防雄性种系中氧化应激介导的病理学

• 批准号: nhmrc : 1138701
• 金额: $ 27.82万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeted-disruption-lipoxygenase-male-germline/1318828
• 关键词: Targeted; disruption; lipoxygenase; enzymes; prevent

An estimated 80 million individuals suffer from infertility globally with at least 50% of these cases due to defects in sperm function. Unfortunately, due to a severe lack of knowledge surrounding sperm biology and dysfunction, no successful curative or preventative measures have been established. My project will study why sperm cells die and investigate new ways to limit cellular stress so we can develop new therapeutic strategies to mitigate the growing problems in male reproductive health.

据估计，全球有8000万人患有不育症，其中至少50%是由于精子功能缺陷造成的。不幸的是，由于严重缺乏关于精子生物学和功能障碍的知识，还没有成功的治疗或预防措施。我的项目将研究精子细胞为什么死亡，并探索限制细胞压力的新方法，这样我们就可以开发新的治疗策略来缓解男性生殖健康中日益严重的问题。