TARGETED EPIGENETIC REACTIVATION OF DORMANT TUMOR SUPPRESSORS: NEW PRECISION THERAPIES FOR LIVER CANCER.

肝癌是所有癌症中死亡率第二高的，其在澳大利亚的发病率正在上升，目前的治疗选择非常有限。最近一项关于肝癌的大型研究强调了几个在肝癌患者中被发现处于休眠状态的保护性“肿瘤抑制基因”。我们正在开发量身定制的疗法，以同时恢复这些基因的活性，以控制这些癌症的扩散和复发，同时使它们对化疗更加敏感。

Liver cancer has the second highest mortality rate of all cancers, its incidence in Australia is increasing, and current treatment options are very limited. A recent, large study of liver cancer has highlighted several protective 'tumour suppressor genes' that are found dormant in liver cancer patients. We are developing tailored therapies to simultaneously restore the activity of these genes to control the spread and relapse of these cancers, while rendering them more sensitive to chemotherapy.