Immune modulation with TLR7/8 agonists

TLR7/8 激动剂的免疫调节

• 批准号: 2794-2009
• 负责人: Babiuk, Lorne
• 金额: $ 4.08万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=419617
• 关键词: Immune; modulation; TLR7; agonists

Currently infectious diseases cause significant economic losses to the livestock industry. Employing a novel molecule that stimulates the animals natural immune responses (innate immunity), we propose to insure that cattle can recover from many infectious agents with less suffering. Secondly, we propose to combine these molecules with vaccines to enhance the immune response to the vaccines. This will dramatically reduce economic losses and animal suffering due to infectious diseases.

目前，传染病给畜牧业造成重大经济损失。 采用一种新的分子，刺激动物的自然免疫反应（先天免疫），我们建议，以确保牛可以从许多传染性病原体恢复较少的痛苦。 其次，我们建议将这些分子与疫苗联合收割机结合，以增强对疫苗的免疫反应。 这将大大减少经济损失和动物因传染病而遭受的痛苦。