Targeting copper homeostasis in aggressive childhood tumours

针对侵袭性儿童肿瘤中的铜稳态

• 批准号: nhmrc : GNT1164960
• 负责人: Dr Orazio Vittorio
• 金额: $ 43.7万
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-copper-homeostasis-childhood-tumours/1349380
• 关键词: Targeting; copper; homeostasis; aggressive; childhood

Despite the use of aggressive therapy, survival rates for neuroblastoma patients are poor, and survivors often experience long-term side effects from the treatment. Copper is essential for the growth of tumour cells. In fact, neuroblastoma cells have high levels of copper compare to normal cells. This project will bring new knowledge and fundamental understanding of the role of copper in neuroblastoma biology, as well as provide new therapeutic strategies for the treatment of this disease.

尽管使用了积极的治疗，神经母细胞瘤患者的存活率很低，幸存者经常经历治疗的长期副作用。铜对肿瘤细胞的生长是必不可少的。事实上，与正常细胞相比，神经母细胞瘤细胞的铜含量很高。该项目将对铜在神经母细胞瘤生物学中的作用带来新的认识和基础认识，并为该疾病的治疗提供新的治疗策略。