Targeting GDNF family ligand (GFL) signalling to treat inflammatory bone pain

与骨髓水肿综合征、骨髓炎、骨关节炎、骨折和骨癌相关的疼痛对澳大利亚和全世界的个人和卫生保健系统造成重大负担。在这个应用程序中，我们将探索特定的信号通路，我们已经确定在神经编码骨痛。这将为合理设计高度特异性的药物提供机会，这些药物能够专门与在这些条件下驱动疼痛的分子相互作用。

Pain associated with bone marrow oedema syndromes, osteomyelitis, osteoarthritis, fractures and bone cancer causes a major burden on individuals and health care systems in Australia and worldwide. In this application, we will explore specific signalling pathways that we have identified in nerves that code bone pain. This will provide an opportunity for the rational design of highly specific drugs capable of interacting exclusively with molecules that drive pain in these conditions.