Targeting inflammation as a biomarker and treatment for Alzheimer's disease

将炎症作为阿尔茨海默病的生物标志物和治疗方法

• 批准号: nhmrc : 1139469
• 金额: $ 48.55万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Targeted Calls
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-inflammation-biomarker-alzheimers-disease/1318984
• 关键词: Targeting; inflammation; biomarker; treatment; Alzheimer

We are undertaking the challenge of using and developing novel animal models in parallel with studies on affected human subjects to elucidate the underlying molecular mechanisms linking the changes in inflammation to amyloid plaques, neurofibrillary tangles and cognitive decline. Understanding these mechanisms will allow us to define the biological pathways involved in the onset and progression of Alzheimer’s disease, and identify potential biomarkers and therapeutic targets.

我们面临的挑战是，在对受影响的人类受试者进行研究的同时，使用和开发新的动物模型，以阐明将炎症变化与淀粉样斑块、神经原纤维缠结和认知能力下降联系起来的潜在分子机制。了解这些机制将使我们能够定义阿尔茨海默病的发生和发展所涉及的生物途径，并确定潜在的生物标记物和治疗靶点。