Targeting lipid signalling receptors to promote remyelination in multiple sclerosis

靶向脂质信号受体促进多发性硬化症的髓鞘再生

• 批准号: nhmrc : 2002660
• 金额: $ 92.59万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-lipid-signalling-multiple-sclerosis/1779954
• 关键词: Targeting; lipid; signalling; receptors; promote

Multiple sclerosis is caused by the immune system mistakenly attacking and depleting myelin, the fatty substance that insulates neurons in our nervous system. To improve MS therapy and open up the possibility for functional recovery, we must develop drugs that protect and regenerate myelin. We will define how the loss of certain key biochemical signals promotes myelin loss in MS, and how drugs that restore those signals may be used to protect and regenerate myelin in people with the disease.

多发性硬化症是由免疫系统错误地攻击和消耗髓磷脂引起的，髓磷脂是一种使我们神经系统中的神经元绝缘的脂肪物质。为了改善MS治疗并为功能恢复开辟可能性，我们必须开发保护和再生髓鞘的药物。我们将定义某些关键生化信号的丢失如何促进MS中的髓鞘丢失，以及如何使用恢复这些信号的药物来保护和再生患有这种疾病的人的髓鞘。