Targeting microRNA-driven mesenchymal to epithelial transition to suppress prostate cancer metastasis

在澳大利亚，前列腺癌每年导致约3000名男性死亡。转移的发展是前列腺癌相关死亡的主要原因，治疗选择有限。在这项研究中，我们将描述一组被称为microrna的分子在前列腺癌转移中的作用。我们还将测试使用称为antagomiRs的新型药物靶向microrna是否是抑制转移从而提高前列腺癌死亡率的有效策略。

Prostate cancer kills ~3,000 men per year in Australia. The development of metastasis is the major cause of prostate cancer-associated death and has limited treatment options. In this study, we will characterise the role of a group of molecules, termed microRNAs, in prostate cancer metastasis. We will also test whether targeting microRNAs using novel drugs termed antagomiRs is an effective strategy to inhibit metastasis and thereby improve prostate cancer mortality.