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Abnormal automaticity and complex entrainment in cardiac cell and tissue models

Abnormal automaticity and complex entrainment in cardiac cell and tissue models
心脏细胞和组织模型中的异常自动化和复杂夹带
批准号:
121654-2009
负责人:
Vinet, Alain
金额:
$1.82万
依托单位:
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2009
资助国家:
加拿大
项目状态:
已结题
起止时间:
2009-01-01 至 2010-12-31

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中文摘要
翻译
心室心肌梗死和缺血占加拿大死亡率的18%。由缺血引起的致死性心律失常占急性死亡的大多数。细胞膜上的静息膜电位和离子浓度差异由离子泵和离子交换器维持。当血流受损时,氧气和能量来源被耗尽,细胞外钾(K+o)积累,使静息膜电位(Vm)去极化,导致健康组织和患病组织之间的电流流动。这种电流与改变的电耦合一起被认为是触发自我维持的重入波和室性心律失常的因素
英文摘要
Ventricular myocardial infarction and ischemia account for 18% of mortality in Canada. Lethal cardiac arrhythmias induced by ischemia account for the majority of deaths in the acute setting. The resting membrane potential and ion concentration differences across the cell membrane are maintained by ion pumps and exchangers. Upon impaired blood flow, oxygen and energy sources are depleted and extracellular potassium (K+o) accumulates such that the resting membrane potential (Vm) depolarises, resulting in a current flow between the healthy and ailing tissue. This current, in conjunction with altered electrical coupling is thought to act as a trigger for self-sustaining reentrant waves and ventricular arrhythmias
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Mathematical models of Abnormal automaticiy in cardiac tissue
  • 批准号:
    RGPIN-2014-05558
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $1.89万
  • 财政年份:
    2018
  • 负责人:
    Vinet, Alain
  • 依托单位:
Mathematical models of Abnormal automaticiy in cardiac tissue
  • 批准号:
    RGPIN-2014-05558
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $1.89万
  • 财政年份:
    2017
  • 负责人:
    Vinet, Alain
  • 依托单位:
Mathematical models of Abnormal automaticiy in cardiac tissue
  • 批准号:
    RGPIN-2014-05558
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $1.89万
  • 财政年份:
    2016
  • 负责人:
    Vinet, Alain
  • 依托单位:
Mathematical models of Abnormal automaticiy in cardiac tissue
  • 批准号:
    RGPIN-2014-05558
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $1.89万
  • 财政年份:
    2015
  • 负责人:
    Vinet, Alain
  • 依托单位:
海外基金