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Abnormal automaticity and complex entrainment in cardiac cell and tissue models

Abnormal automaticity and complex entrainment in cardiac cell and tissue models
心脏细胞和组织模型中的异常自动化和复杂夹带
批准号:
121654-2009
负责人:
Vinet, Alain
金额:
$1.82万
依托单位:
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2009
资助国家:
加拿大
项目状态:
已结题
起止时间:
2009-01-01 至 2010-12-31

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中文摘要
翻译
在加拿大,室性心肌梗死和缺血占死亡率的18%。在急性发作中,由缺血引起的致命性心律失常是死亡的主要原因。静止膜电位和跨细胞膜的离子浓度差由离子泵和交换器维持。当血流受损时,氧气和能源耗尽,细胞外钾(K+o)积累,静息膜电位(Vm)去极化,导致健康和患病组织之间的电流流动。这种电流与改变的电耦合一起被认为是自我维持的折返波和室性心律失常的触发因素。
英文摘要
Ventricular myocardial infarction and ischemia account for 18% of mortality in Canada. Lethal cardiac arrhythmias induced by ischemia account for the majority of deaths in the acute setting. The resting membrane potential and ion concentration differences across the cell membrane are maintained by ion pumps and exchangers. Upon impaired blood flow, oxygen and energy sources are depleted and extracellular potassium (K+o) accumulates such that the resting membrane potential (Vm) depolarises, resulting in a current flow between the healthy and ailing tissue. This current, in conjunction with altered electrical coupling is thought to act as a trigger for self-sustaining reentrant waves and ventricular arrhythmias
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Mathematical models of Abnormal automaticiy in cardiac tissue
  • 批准号:
    RGPIN-2014-05558
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $1.89万
  • 财政年份:
    2018
  • 负责人:
    Vinet, Alain
  • 依托单位:
Mathematical models of Abnormal automaticiy in cardiac tissue
  • 批准号:
    RGPIN-2014-05558
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $1.89万
  • 财政年份:
    2017
  • 负责人:
    Vinet, Alain
  • 依托单位:
Mathematical models of Abnormal automaticiy in cardiac tissue
  • 批准号:
    RGPIN-2014-05558
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $1.89万
  • 财政年份:
    2016
  • 负责人:
    Vinet, Alain
  • 依托单位:
Mathematical models of Abnormal automaticiy in cardiac tissue
  • 批准号:
    RGPIN-2014-05558
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $1.89万
  • 财政年份:
    2015
  • 负责人:
    Vinet, Alain
  • 依托单位:
海外基金