Targeting remodelling in chronic obstructive pulmonary disease (COPD), chronic asthma and idiopathic pulmonary fibrosis (IPF)

针对慢性阻塞性肺病 (COPD)、慢性哮喘和特发性肺纤维化 (IPF) 的重塑

• 批准号: nhmrc : 1138402
• 金额: $ 26.14万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-remodelling-chronic-fibrosis-ipf/1318741
• 关键词: Targeting; remodelling; chronic; obstructive; pulmonary

Lung diseases (emphysema, asthma & pulmonary fibrosis) are major burdens on Australian community and economy. Airway remodelling/wounding is a key feature of all these diseases. Patients experience severe breathlessness seriously impacting quality of life and frequently leading to death. We will assess the potential of new targets (including IL-33), & therapy in suppressing wounding in experimental models. This may lead to a new treatment to reverse or prevent lung diseases.

肺部疾病（肺气肿、哮喘和肺纤维化）是澳大利亚社会和经济的主要负担。气道重塑/创伤是所有这些疾病的关键特征。患者经历严重呼吸困难，严重影响生活质量，并经常导致死亡。我们将评估新靶点（包括IL-33）的潜力，以及在实验模型中抑制创伤的治疗。这可能会导致一种新的治疗方法来逆转或预防肺部疾病。