Targeting the TWEAK/Fn14 signalling pathway as a novel therapeutic strategy to prevent chronic liver disease progression.

点击翻译按钮获取中文摘要

TWEAK/Fn14 signalling critically regulates inflammation, fibrosis and liver progenitor cell responses - all processes involved in progressive chronic liver injury. In this study, we will now define the involved cell populations, identify the underlying mechanisms and test pharmacological targeting of this pathway as a novel therapeutic avenue to inhibit chronic liver disease progression to cancer. Importantly, we will also assess translatability of our findings into the human setting.