Targeting unhelpful pain beliefs to promote physical activity in people with knee osteoarthritis: a multicentre, randomised controlled trial with cost-effectiveness analysis

缺乏运动是膝骨性关节炎(OA)患者的一个严重问题：他们没有足够的活动来维持他们的健康，而且不运动经常会使他们的OA症状变得更糟。在一项大型临床试验中，我们将测试一种有前景的新疗法-疼痛生物学教育-其改善体力活动和疼痛的能力。我们的试点工作显示了有希望的结果：在139名膝骨性关节炎患者中，这种治疗增加了活动量，减少了疼痛，并持续了长达一年的改善。

Physical inactivity is a serious problem in people with knee osteoarthritis (OA): they are not active enough to maintain their health and inactivity often makes their OA symptoms worse. In a large clinical trial, we will test a promising new treatment – pain biology education – for its ability to improve physical activity and pain. Our pilot work shows promising results: in 139 people with knee OA this treatment increases activity and reduces pain with improvements continuing for up to 1 year.