Targeting unhelpful pain beliefs to promote physical activity in people with knee osteoarthritis: a multicentre, randomised controlled trial with cost-effectiveness analysis

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Physical inactivity is a serious problem in people with knee osteoarthritis (OA): they are not active enough to maintain their health and inactivity often makes their OA symptoms worse. In a large clinical trial, we will test a promising new treatment – pain biology education – for its ability to improve physical activity and pain. Our pilot work shows promising results: in 139 people with knee OA this treatment increases activity and reduces pain with improvements continuing for up to 1 year.