Functional characterization of Salmonella enterica RdoA, a Cpx-regulated kinase

Cpx 调节激酶肠沙门氏菌 RdoA 的功能表征

• 批准号: 184228-2008
• 负责人: Martin, Nancy
• 金额: $ 2.92万
• 依托单位: Queen's University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=423066
• 关键词: Functional; characterization; Salmonella; enterica; RdoA

Bacteria experience rapid and extreme changes in their surrounding environment and survive these changes by adapting. The major goal of this research is to understand the cellular responses that allow the bacterium to adapt to changes in the environment. To survive in these different environments Salmonella enterica, a common cause of food poisoning, utilizes a senor system that uses phosphoryl groups to relay messages inside the cell that activate coping mechanisms that cause new proteins to be made.

细菌在其周围环境中经历快速和极端的变化，并通过适应这些变化而生存下来。这项研究的主要目标是了解允许细菌适应环境变化的细胞反应。为了在这些不同的环境中生存，肠道沙门氏菌（食物中毒的常见原因）利用一种传感器系统，该系统使用磷酰基在细胞内传递信息，激活应对机制，从而产生新的蛋白质。