The role of LINE encoded natural antisense transcripts in immune regulation

LINE编码的天然反义转录本在免疫调节中的作用

• 批准号: nhmrc : 2004306
• 金额: $ 93.49万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/the-role-line-immune-regulation/1780320
• 关键词: role; LINE; encoded; natural; antisense

Genetic information underpins all life on earth and is processed to make proteins, which determine the characteristics of an organism. However, only about 2% of our whole genome is made up of genes that encode proteins; the other 98% is non-coding and its function remains poorly understood. This proposal aims to utilize cutting edge genomic technologies to generate new knowledge about how the non-coding genome regulates the expression of protein coding genes in human autoimmune disease.

遗传信息是地球上所有生命的基础，并被加工成蛋白质，蛋白质决定了生物体的特征。然而，我们的整个基因组中只有大约2%是由编码蛋白质的基因组成的;其他98%是非编码的，其功能仍然知之甚少。该提案旨在利用尖端的基因组学技术来产生关于非编码基因组如何调节人类自身免疫性疾病中蛋白质编码基因表达的新知识。