Theoretical and Computational Studies on Voltage-Gated Potassium (Kv) Channels

电压门控钾 (Kv) 通道的理论和计算研究

• 批准号: nhmrc : 585453
• 负责人: Prof Shin-Ho Chung
• 金额: $ 28.53万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/theoretical-computational-studies-kv-channels/76637
• 关键词: Theoretical; Computational; Studies; Voltage; Gated

The primary aim of the proposed projects is to understand how biological ion channels work. All electrical activities in the nervous system, including communication between cells and influences of hormones and drugs on cell function, are regulated by the opening and closing of ion channels. We will study, applying rigorous physical principles and engineering methods and using powerful supercomputers, a class of biological ion channels, known as the voltage-activated potassium channels.

拟议项目的主要目的是了解生物离子通道如何工作。神经系统中的所有电活动，包括细胞之间的通信以及激素和药物对细胞功能的影响，都受到离子通道的打开和关闭的调节。我们将应用严格的物理原理和工程方法，并使用强大的超级计算机，研究一类生物离子通道，称为电压激活钾通道。