Thioredoxin Interacting Protein: A Novel Regulator of Angiogenesis and Impaired Neovascularisation in Diabetes Mellitus

硫氧还蛋白相互作用蛋白：糖尿病血管生成和新血管形成受损的新型调节剂

• 批准号: nhmrc : 537537
• 负责人: Dr Louise Dunn
• 金额: $ 19.51万
• 依托单位: Victor Chang Cardiac Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/thioredoxin-interacting-protein-diabetes-mellitus/115860
• 关键词: Thioredoxin; Interacting; Protein; Novel; Regulator

Heart disease is the leading cause of death and treatment options such as bypass surgery are unsuitable for many sufferers, particularly those with diabetes. This project investigates the regulation of new blood vessel growth through the action of antioxidants and also examines the contribution of adult stem cells to this process. Regulating new blood vessel growth provides a novel means to overcome current problems in the management of both non-diabetic and diabetic patients with heart disease.

心脏病是导致死亡的主要原因，心脏搭桥手术等治疗方案不适合许多患者，尤其是糖尿病患者。该项目研究通过抗氧化剂的作用对新血管生长的调节，并研究成体干细胞对这一过程的贡献。调节新血管的生长为克服当前非糖尿病和糖尿病合并心脏病患者的管理问题提供了一种新的手段。