Tissue fibrosis and exercise in Polycystic Ovary Syndrome: Linking mechanisms to therapy

多囊卵巢综合症的组织纤维化和运动：将机制与治疗联系起来

• 批准号: nhmrc : GNT1156329
• 金额: $ 99.09万
• 依托单位: Victoria University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/tissue-fibrosis-exercise-mechanisms-therapy/1378914
• 关键词: Tissue; fibrosis; exercise; Polycystic; Ovary

Polycystic ovary syndrome (PCOS) affects 1 million Australian women. PCOS via insulin resistance (IR) is implicated in diabetes, infertility and menstrual disturbance. Obesity is synergistic with PCOS worsening health trajectories. Tissue fibrosis is causally linked to PCOS, but the details and the implications for therapy need urgent research. This project will identify the role of muscle fibrosis in PCOS specific IR, and evaluate high-intensity interval exercise as a promising new therapy.

多囊卵巢综合征（PCOS）影响着100万澳大利亚妇女。多囊卵巢综合征通过胰岛素抵抗（IR）与糖尿病、不孕症和月经紊乱有关。肥胖与多囊卵巢综合征恶化的健康轨迹是协同作用的。组织纤维化与多囊卵巢综合征有因果关系，但其细节和治疗意义需要紧急研究。该项目将确定肌肉纤维化在PCOS特异性IR中的作用，并评估高强度间歇运动作为一种有前景的新疗法。