Tissue fibrosis and exercise in Polycystic Ovary Syndrome: Linking mechanisms to therapy

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Polycystic ovary syndrome (PCOS) affects 1 million Australian women. PCOS via insulin resistance (IR) is implicated in diabetes, infertility and menstrual disturbance. Obesity is synergistic with PCOS worsening health trajectories. Tissue fibrosis is causally linked to PCOS, but the details and the implications for therapy need urgent research. This project will identify the role of muscle fibrosis in PCOS specific IR, and evaluate high-intensity interval exercise as a promising new therapy.