Phosphorylation of Nck

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The human body is composed of various tissues, which in turn consist of cells that have specialized functions. The coordinated regulation of the human cell functions involves biochemical processes mediating the modification of the activity of cellular proteins. One such important modification that affects protein activity implicates the phosphorylation of these specific proteins by specialized enzymes that are defined as protein kinases. Our laboratory is interested in the basic study of protein phosphorylation and in the identification of the protein kinases participating in this process. As a working model, we focus on the small protein Nck that we have found heavily phosphorylated in various stress conditions known to activate a specific subset of protein kinases. Our research will benefit the whole scientific community by providing a detailed understanding of fundamental mechanisms regulating the human cell functions.