BEYOND TRADITIONAL GENE BOUNDARIES: Establishing the importance of enhancer epigenetic reprogramming and atypical long-range interactions in cancer cells.

超越传统基因界限：确立增强子表观遗传重编程和癌细胞中非典型远程相互作用的重要性。

• 批准号: nhmrc : 1051757
• 负责人: Dr Phillippa Taberlay
• 金额: $ 47.91万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/traditional-gene-boundaries-cancer-cells/112235
• 关键词: BEYOND; TRADITIONAL; GENE; BOUNDARIES; Establishing

Effective prevention and treatment strategies for cancer are still needed to combat this disease. By determining how DNA is packaged differently in prostate cancer cells relative to normal prostate cells, will allow us to understand how the specific location of regulatory centres or factories affects gene behavior. Unlike genetic defects in cancer, physical and chemical modifications to DNA in these centres are potentially reversible, providing an opportunity to develop novel therapeutics and diagnostic tools.

仍然需要有效的癌症预防和治疗策略来对抗这种疾病。通过确定DNA在前列腺癌细胞中相对于正常前列腺细胞如何不同地包装，将使我们能够了解调控中心或工厂的具体位置如何影响基因行为。与癌症的遗传缺陷不同，这些中心对DNA的物理和化学修饰可能是可逆的，为开发新的治疗和诊断工具提供了机会。