Trajectories of circulating testosterone and estradiol and implications for the health of ageing men.

循环睾酮和雌二醇的轨迹及其对老年男性健康的影响。

• 批准号: nhmrc : 1060557
• 负责人: A/Pr Kieran Mccaul
• 金额: $ 15.67万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/trajectories-circulating-testosterone-ageing-men/454838
• 关键词: Trajectories; circulating; testosterone; estradiol; implications

Older men with low testosterone levels have more ill-health. However, it is unclear whether age causes testosterone levels to fall, predisposing to disease, or whether changes in hormone levels result from pre-existing illness. We previously measured sex hormone levels in older men in Western Australia in 2001-04. By measuring hormone levels in new samples from 1400 of these men taken in 2011-12, we will clarify trajectories of sex hormone levels and their relationship to healthy ageing.

睾丸素水平较低的老年男性健康状况更差。然而，目前尚不清楚年龄是否会导致睾酮水平下降，从而导致疾病易感，或者激素水平的变化是否源于既往疾病。我们之前在2001-04年间测量了西澳大利亚州老年男性的性激素水平。通过测量2011-12年度采集的1400名男性新样本中的激素水平，我们将厘清性激素水平的轨迹及其与健康老龄化的关系。