Tranexamic acid and hypotension-avoidance to prevent death and major complications after noncardiac surgery (PeriOperative ISchemic Evaluation-3 – the POISE-3 Trial)

出血和低血压是麻醉和手术常见的危险并发症。我们建议进行一项大型国际研究，以确定氨甲环酸（TXA）是否是一种安全有效的预防出血药物，以及预防低血压是否能有效减少老年重病患者接受重大非心脏手术后的死亡和主要并发症。这项研究有可能改善全球数百万患者的临床结果

Bleeding and low blood pressure are common and dangerous complications of anaesthesia and surgery. We propose a large international study to determine if tranexamic acid (TXA) is a safe and efficacious drug to prevent bleeding, and whether preventing low blood pressure is efficacious in reducing death and major complications after surgery in older sicker patients having major noncardiac surgery. This study has the potential to improve clinical outcomes for millions of patients worldwide