Tranexamic acid and hypotension-avoidance to prevent death and major complications after noncardiac surgery (PeriOperative ISchemic Evaluation-3 – the POISE-3 Trial)

出血和低血压是麻醉和手术的常见和危险的并发症。我们提议进行一项大型国际研究，以确定氨甲环酸(TXA)是否是预防出血的安全有效的药物，以及预防低血压在减少老年非心脏手术患者手术后的死亡率和主要并发症方面是否有效。这项研究有可能改善全球数百万患者的临床结果

Bleeding and low blood pressure are common and dangerous complications of anaesthesia and surgery. We propose a large international study to determine if tranexamic acid (TXA) is a safe and efficacious drug to prevent bleeding, and whether preventing low blood pressure is efficacious in reducing death and major complications after surgery in older sicker patients having major noncardiac surgery. This study has the potential to improve clinical outcomes for millions of patients worldwide