Transcriptional regulation of the Complement Receptor 2 gene (CR2/CD21) during B cell lineage committment

B 细胞谱系定型过程中补体受体 2 基因 (CR2/CD21) 的转录调控

• 批准号: nhmrc : 303206
• 负责人: Dr Daniela Ulgiati
• 金额: $ 31.11万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/transcriptional-regulation-complement-lineage-committment/94633
• 关键词: Transcriptional; regulation; Complement; Receptor; gene

The complement system is a very important pathway within the human immune system. One of the receptors within this system is complement receptor 2 or CR2. CR2 has not only been shown to be important within the inflammatory response and defence against microbes but is also important in normal generation of a B cell immune response . B cells not only produce antibodies against foreign organisms but in some cases dysfunction of the B cell can bring about autoimmunity by production of antibodies against self tissues and cells . How the CR2 gene turns on expression on different cells within the immune system is complex. The amount of receptor on the surface of antibody producing B cells has important implications to B cell biology. As CR2 expression is turned on at an important point within the antibody producing B cell and the levels of this receptor can influence B cell function, understanding how this gene is regulated is important.

补体系统是人体免疫系统中一条非常重要的途径。这个系统中的一个受体是补体受体2或CR2。CR2已被证明不仅在炎症反应和对微生物的防御中很重要，而且在B细胞免疫反应的正常产生中也很重要。B细胞不仅产生针对外来生物的抗体，而且在某些情况下，B细胞功能障碍可通过产生针对自身组织和细胞的抗体而导致自身免疫。CR2基因如何在免疫系统内的不同细胞上启动表达是复杂的。产生抗体的B细胞表面受体的数量对B细胞生物学有重要意义。由于CR2的表达是在产生抗体的B细胞内的一个重要点上启动的，而且该受体的水平可以影响B细胞的功能，因此了解该基因是如何调控的是很重要的。