Investigations into mammalian ovarian follicle development and interactions
哺乳动物卵巢卵泡发育和相互作用的研究
基本信息
- 批准号:288304-2009
- 负责人:
- 金额:$ 2.04万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2009
- 资助国家:加拿大
- 起止时间:2009-01-01 至 2010-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The mammalian female ovary is a heterogeneous organ containing the female germ cells (eggs, oocytes) enclosed in complex structures (follicles), whose ultimate purpose is to provide oocytes capable of being fertilized and producing healthy offspring. There are multiple stages of follicle development and differentiation through which ovarian follicles must pass before producing a mature oocyte. Through signals that come from within or outside the ovary, a steady state of follicular development and growth is established with respect to numbers and types of growing follicles. But the majority of follicles stay dormant, in the earliest stages, waiting for their turn. The mechanisms underlying early follicle development remain poorly understood. Thus, the long-term goal of the proposed research program is to elucidate the mechanisms involved in inter-cellular and inter-follicular interactions that maintain steady-state populations of ovarian follicles. Investigations will explore the role(s) of members of the Transforming Growth Factor-beta superfamily of growth/inhibitory factors and their receptors in regulating ovarian follicular development. This is being accomplished by manipulating follicle populations using both mouse ovaries cultured outside the body and exposing mice to things that specifically kill certain stages of ovarian follicles. Studies are also examining which enzymes are active in the oocyte which maintain its health. The research program will provide greater understanding of molecular signaling involved in ovarian physiology, which will impact both our basic concepts of reproductive biology and the tools we have for use in the clinical setting.
哺乳动物雌性卵巢是一个异质性器官,包含封闭在复杂结构(卵泡)中的雌性生殖细胞(卵子,卵母细胞),其最终目的是提供能够受精并产生健康后代的卵母细胞。卵泡发育和分化有多个阶段,卵泡在产生成熟卵母细胞之前必须经过这些阶段。通过来自卵巢内或卵巢外的信号,卵泡发育和生长的稳定状态根据生长卵泡的数量和类型建立。但是大多数卵泡在最早的阶段处于休眠状态,等待轮到它们。 早期卵泡发育的机制仍然知之甚少。因此,拟议的研究计划的长期目标是阐明维持稳态卵泡群体的细胞间和卵泡间相互作用的机制。研究将探索转化生长因子-β超家族的生长/抑制因子及其受体在调节卵巢卵泡发育中的作用。这是通过使用体外培养的小鼠卵巢和将小鼠暴露于专门杀死某些阶段卵泡的物质来操纵卵泡数量来实现的。 研究还在检查卵母细胞中哪些酶是活跃的,以维持其健康。 该研究计划将提供对卵巢生理学所涉及的分子信号传导的更深入了解,这将影响我们对生殖生物学的基本概念和我们在临床环境中使用的工具。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Devine, Patrick其他文献
TFG::ALK fusion in ALK positive large B-cell lymphoma: a case report and review of literature.
- DOI:
10.3389/fonc.2023.1174606 - 发表时间:
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- 影响因子:4.7
- 作者:
Xiao, Andrew;Shahmarvand, Nahid;Nagy, Alexandra;Kumar, Jyoti;Van Ziffle, Jessica;Devine, Patrick;Huang, Franklin;Lezama, Lhara;Li, Peng;Ohgami, Robert S. S. - 通讯作者:
Ohgami, Robert S. S.
TP53 structural variants in metastatic prostatic carcinoma
- DOI:
10.1371/journal.pone.0218618 - 发表时间:
2019-06-19 - 期刊:
- 影响因子:3.7
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Sirohi, Deepika;Devine, Patrick;Stohr, Bradley A. - 通讯作者:
Stohr, Bradley A.
Contributory Fault under International Law: A Gateway for Human Rights in ISDS?
- DOI:
10.1093/icsidreview/siaa005 - 发表时间:
2020-12-01 - 期刊:
- 影响因子:1.1
- 作者:
El-Hosseny, Farouk;Devine, Patrick - 通讯作者:
Devine, Patrick
Sarcomatous Meningioma: Diagnostic Pitfalls and the Utility of Molecular Testing
- DOI:
10.1093/jnen/nlab053 - 发表时间:
2021-06-12 - 期刊:
- 影响因子:3.2
- 作者:
Lucas, Calixto-Hope G.;Devine, Patrick;Perry, Arie - 通讯作者:
Perry, Arie
Devine, Patrick的其他文献
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{{ truncateString('Devine, Patrick', 18)}}的其他基金
Investigations into mammalian ovarian follicle development and interactions
哺乳动物卵巢卵泡发育和相互作用的研究
- 批准号:
288304-2009 - 财政年份:2010
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Investigation of mammalian ovarian follicle development and interactions.
哺乳动物卵巢卵泡发育和相互作用的研究。
- 批准号:
288304-2004 - 财政年份:2008
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Investigation of mammalian ovarian follicle development and interactions.
哺乳动物卵巢卵泡发育和相互作用的研究。
- 批准号:
288304-2004 - 财政年份:2007
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Investigation of mammalian ovarian follicle development and interactions.
哺乳动物卵巢卵泡发育和相互作用的研究。
- 批准号:
288304-2004 - 财政年份:2006
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Investigation of mammalian ovarian follicle development and interactions.
哺乳动物卵巢卵泡发育和相互作用的研究。
- 批准号:
288304-2004 - 财政年份:2005
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Improvement and enlargement of core culture facilities for research in human and environmental health
改善和扩大人类和环境健康研究的核心培养设施
- 批准号:
330802-2006 - 财政年份:2005
- 资助金额:
$ 2.04万 - 项目类别:
Research Tools and Instruments - Category 1 (<$150,000)
Investigation of mammalian ovarian follicle development and interactions.
哺乳动物卵巢卵泡发育和相互作用的研究。
- 批准号:
288304-2004 - 财政年份:2004
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Microscopy instrumentation for investigations into mammalian ovarian follicle development and physiology
用于研究哺乳动物卵泡发育和生理学的显微镜仪器
- 批准号:
300278-2004 - 财政年份:2003
- 资助金额:
$ 2.04万 - 项目类别:
Research Tools and Instruments - Category 1 (<$150,000)
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