From transcriptome metanalysis to targeted therapies in triple negative breast cancer

我们识别了一个基因表达特征，一个基因指纹，它识别了受到非常侵袭性形式的乳腺癌影响的患者。在这个项目中，我们将开发一种临床相关的测试，可以用于指导针对侵袭性类型的乳腺癌的治疗计划，以提高存活率。此外，我们将针对这些积极的亚型，验证未来药物开发的新靶点。

We identified a gene expression signature, a genetic fingerprint, that identifies patients who are affected by very aggressive forms of breast cancer. In this project, we will develop a clinically relevant test that can be used to guide treatment planning against aggressive types of breast cancer to improve survival rates. In addition we will validate new and novel targets for future drug development against these aggressive subtypes.