Inorganic and hybrid molecules and materials

无机和杂化分子和材料

• 批准号: 312640-2009
• 负责人: Jones, Nathan
• 金额: $ 2.91万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=428326
• 关键词: Inorganic; hybrid; molecules; materials

Just as a person's hands are mirror images of one another, many molecules are also "handed," or chiral. Chiral molecules are important because they are the building blocks of much of biology (e.g., DNA, proteins and sugars) and many interactions, such as those between drugs and their specific targets in the body, depend upon discriminating recognition events between chiral components: only one "hand" of a chiral molecule is recognised, while the other is rejected. Our research takes an integrated approach to the development of fundamentally new catalysts for the selective production of single "hands" of chiral molecules.

就像人的手是彼此的镜像一样，许多分子也是“手”，或手性的。手性分子很重要，因为它们是许多生物学的基石（例如，DNA、蛋白质和糖）和许多相互作用（如药物与其体内特定靶点之间的相互作用）取决于手性组分之间的识别事件：手性分子只有一只“手”被识别，而另一只“手”被排斥。我们的研究采取了综合的方法来开发全新的催化剂，用于选择性生产手性分子的单“手”。