Selective fluorination chemistry: a tool for creating bioactive, shape-controlled peptides
Selective fluorination chemistry: a tool for creating bioactive, shape-controlled peptides
选择性氟化化学：创建生物活性、形状控制肽的工具
批准号：
DE120101653
负责人：
A/Prof Luke Hunter
金额：
$26.91万
依托单位国家：
澳大利亚
项目类别：
Discovery Early Career Researcher Award
财政年份：
2012
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2012-03-31 至 2015-03-31
中文摘要
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英文摘要
Fluorine atoms are desirable substituents in drug candidates because they can increase metabolic stability and hydrophobicity, and because they can be used to constrain molecules into optimal bioactive conformations. These concepts are being exploited to create shape-controlled peptides with applications in anti-cancer and anti-microbial therapy.
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会议论文
Fine-tuning the conformations of cyclic peptides: a paradigm for optimising synthetic efficiency and biological activity
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批准号：DP140103962
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项目类别：Discovery Projects
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资助金额：$24.12万
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财政年份：2014
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负责人：A/Prof Luke Hunter
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依托单位：
海外基金
