Selective fluorination chemistry: a tool for creating bioactive, shape-controlled peptides

选择性氟化化学：创建生物活性、形状控制肽的工具

• 批准号: DE120101653
• 负责人: A/Prof Luke Hunter
• 金额: $ 26.91万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-03-31 至 2015-03-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE120101653
• 关键词: Selective; fluorination; chemistry; tool; creating

Fluorine atoms are desirable substituents in drug candidates because they can increase metabolic stability and hydrophobicity, and because they can be used to constrain molecules into optimal bioactive conformations. These concepts are being exploited to create shape-controlled peptides with applications in anti-cancer and anti-microbial therapy.

氟原子是候选药物中理想的取代基，因为它们可以增加代谢稳定性和疏水性，并且因为它们可以用于将分子约束为最佳生物活性构象。这些概念正在被利用来创造形状控制的肽，并应用于抗癌和抗微生物治疗。