TRF2 protein and t-loop replication in Alternative Lengthening of Telomeres

TRF2 蛋白和 T 环复制在端粒替代延长中的作用

• 批准号: nhmrc : 477106
• 负责人: Dr Lorel Colgin
• 金额: $ 26.55万
• 依托单位: Children's Medical Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/trf2-protein-t-lengthening-telomeres/99175
• 关键词: TRF2; protein; loop; replication; Alternative

Telomere loss acts as a clock telling cells when to stop proliferating. Cancer cells ignore this clock and grow indefinitely by preventing the normal loss of telomeres. Little is known about one of the methods cancers use to preserve telomeres, called ALT, which is employed by some brain tumours and other cancers. We will determine if the TRF2 protein is involved in controlling ALT. This will lay the basis for future anti-cancer treatments targeted at ALT.

端粒缺失就像一个时钟，告诉细胞何时停止增殖。癌细胞忽略了这个时钟，通过阻止端粒的正常丢失而无限期地生长。人们对癌症用来保存端粒的一种方法，即ALT，知之甚少，这种方法被一些脑肿瘤和其他癌症所采用。我们将确定TRF2蛋白是否参与控制ALT。这将为未来针对ALT的抗癌治疗奠定基础。