Trophoblast cell-cell fusion in preeclampsia

先兆子痫中的滋养层细胞-细胞融合

• 批准号: nhmrc : GNT1130255
• 负责人: Dr David Simmons
• 金额: $ 48.73万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/trophoblast-cell-cell-fusion-preeclampsia/1347802
• 关键词: Trophoblast; cell; fusion; preeclampsia

Cell-cell fusion is critical for the development and transport capacity of the placenta during pregnancy. Impairments in this process occur in pregnancy complications such as preeclampsia (PE). We have identified a novel pathway (LY6E) regulating placental cell-cell fusion which is also dysregulated in human pregnancies complicated by PE. In the current proposal we will investigate the mechanisms by which LY6E mediates cell-cell fusion and examine its role in the development of PE.

细胞-细胞融合对于妊娠期间胎盘的发育和运输能力至关重要。这一过程的障碍发生在妊娠并发症，如先兆子痫（PE）。我们已经确定了一个新的途径（LY 6 E）调节胎盘细胞-细胞融合，这也是失调的人类妊娠并发PE。在目前的建议中，我们将研究LY 6 E介导细胞-细胞融合的机制，并研究其在PE发展中的作用。