Tumour-on-a-chip models for ex-vivo profiling of immune checkpoint blockades

用于免疫检查点阻断的离体分析的芯片上肿瘤模型

• 批准号: nhmrc : 1143377
• 金额: $ 29.14万
• 依托单位: University of Technology Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/tumour-on-a-checkpoint-blockades/1319938
• 关键词: Tumour; chip; models; ex; vivo

The overall goal of this project is to build novel 3D biochips to culture primary human tumors with their immune cells, and to investigate patient specific responses to immune checkpoint blockade ex-vivo. Since there are currently no validated methodologies to study immunotherapy response in patient-derived cancer specimens, this proposal has the potential to provide a state-of-the art technology for the ‘personalization’ of immunotherapy.

该项目的总体目标是构建新型3D生物芯片，以培养具有免疫细胞的原发性人类肿瘤，并研究患者对免疫检查点阻断的体外特异性反应。由于目前还没有经过验证的方法来研究患者来源的癌症标本中的免疫治疗反应，因此该提案有可能为免疫治疗的“个性化”提供最先进的技术。