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Molecular determinants of ku function in non-homologous end-joining and DNA damage signaling pathways

Molecular determinants of ku function in non-homologous end-joining and DNA damage signaling pathways
非同源末端连接和 DNA 损伤信号通路中 ku 功能的分子决定因素
批准号：
355799-2008
负责人：
SchildPoulter, Caroline
金额：
$2.19万
依托单位：
University of Western Ontario
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Individual
财政年份：
2009
资助国家：
加拿大
项目状态：
已结题
起止时间：
2009-01-01 至 2010-12-31
来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=431768
关键词：
Moleculardeterminantskufunctionnon

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英文摘要
Ku is an abundant, ubiquitous factor that has been remarkably conserved throughout evolution as it has been identified in all organisms from bacteria to man. Ku is a complex of two proteins that plays an essential role in the repair of double-strand DNA breaks, a form of DNA damage in which both strands of the double helix break, leading to chromosome rearrangements and, ultimately, genomic instability.
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Molecular events regulated by the Ku heterodimer in non-homologous end-joining and DNA damage signaling pathways
  • 批准号：
    RGPIN-2018-05518
  • 项目类别：
    Discovery Grants Program - Individual
  • 资助金额：
    $3.64万
  • 财政年份：
    2022
  • 负责人：
    SchildPoulter, Caroline
  • 依托单位：
    University of Western Ontario
Molecular events regulated by the Ku heterodimer in non-homologous end-joining and DNA damage signaling pathways
  • 批准号：
    RGPIN-2018-05518
  • 项目类别：
    Discovery Grants Program - Individual
  • 资助金额：
    $3.64万
  • 财政年份：
    2021
  • 负责人：
    SchildPoulter, Caroline
  • 依托单位：
    University of Western Ontario
Molecular events regulated by the Ku heterodimer in non-homologous end-joining and DNA damage signaling pathways
  • 批准号：
    RGPIN-2018-05518
  • 项目类别：
    Discovery Grants Program - Individual
  • 资助金额：
    $3.64万
  • 财政年份：
    2020
  • 负责人：
    SchildPoulter, Caroline
  • 依托单位：
    University of Western Ontario
Molecular events regulated by the Ku heterodimer in non-homologous end-joining and DNA damage signaling pathways
  • 批准号：
    522665-2018
  • 项目类别：
    Discovery Grants Program - Accelerator Supplements
  • 资助金额：
    $5.83万
  • 财政年份：
    2019
  • 负责人：
    SchildPoulter, Caroline
  • 依托单位：
    University of Western Ontario
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