Formation of a hypocholesterolemizing product based on chitosan

基于壳聚糖的降胆固醇产品的形成

• 批准号: 363996-2007
• 负责人: Gagnon, Jonathan
• 金额: $ 4.14万
• 依托单位: Université du Québec à Rimouski
• 依托单位国家: 加拿大
• 项目类别: Idea to Innovation
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=434112
• 关键词: Formation; hypocholesterolemizing; product; based; chitosan

Hypercholesterolemia is the main risk factor of cardiovascular diseases that is a major cause of death in Western society. The invention consists to develop new chitosan derivatives from a new patented technology o synthesis. These derivatives will allow decreasing of blood cholesterol level by precipitation of bile acids in intestine with low side effects. The synthesized product is an improvement of low molecular weight (LMW) chitosan already used for low to moderate hypercholesterolemia. Developed synthesis methodologies will also be useful for the utilization of chitosan derivatives in various applications.

高胆固醇血症是心血管疾病的主要危险因素，是西方社会的主要死亡原因。本发明是从一种新的合成专利技术开发新的壳聚糖衍生物。这些衍生物将允许通过在肠中沉淀胆汁酸来降低血液胆固醇水平，副作用低。合成的产品是低分子量（LMW）壳聚糖已经用于低至中度高胆固醇血症的改进。开发的合成方法也将是有用的壳聚糖衍生物在各种应用中的利用。