Impact on the biology of mucosal tolerance in exposure to haptenated antigens

点击翻译按钮获取中文摘要

This research program is designed to investigate the cellular and molecular mechanisms by which haptenated antigens interfere with the biological aspects of mucosal tolerance. Both tolerogenic dendritic cells and regulatory T cells play a critical role in the establishment/maintenance of mucosal tolerance; the latter plays a central role in maintaining the homeostasis in the body. Defect of either regulatory T cells or tolerogenic dendritic cells plays a critical role in skewed cellular responses.