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Uncovering the Function of Susceptibility Variants in Alzheimer's Disease: From GWAS to Cell-Type Specific eQTLs and mQTLs

Uncovering the Function of Susceptibility Variants in Alzheimer's Disease: From GWAS to Cell-Type Specific eQTLs and mQTLs
揭示阿尔茨海默病易感性变异的功能:从 GWAS 到细胞类型特异性 eQTL 和 mQTL
批准号:
nhmrc : 1102821
负责人:
金额:
$44.53万
依托单位国家:
澳大利亚
项目类别:
Targeted Calls
财政年份:
2016
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2016-01-01 至 2020-12-31

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中文摘要
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英文摘要
This project will investigate some of the genetic and epigenetic changes that occur inside certain brain cells that make them selectively vulnerable to Alzheimer's disease, in order to better understand the mechsnisms that give origin to the disease and identify possible targets for precision therapies.
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原生动物四膜虫生殖小核(germline nucleus)体功能(somatic function)的分子基础研究