AMPK regulation of metabolism

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Canadian society is experiencing an epidemic of obesity that is contributing to diabetes, cardiovascular disease and premature death. It has been known for many years that exercise can prevent diabetes and cardiovascular disease however the molecular events mediating this effect are not known. Recent associative evidence has suggested that a potential mediator of the beneficial effects of exercise may be the AMP-activated protein kinase signalling pathway. In the current study we intend to investigate the effects of exercise on fat metabolism in mice with deficient AMPK signalling to determine whether this is the critical enzyme responsible for the beneficial effects of exercise. A better understanding of the molecular mechanisms mediating the beneficial effects of exercise may lead to the design of new therapeutics for the treatment of diabetes and cardiovascular disease.