AMPK regulation of metabolism

AMPK 调节代谢

• 批准号: 371870-2009
• 负责人: Steinberg, Gregory
• 金额: $ 2.55万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=434998
• 关键词: AMPK; regulation; metabolism

Canadian society is experiencing an epidemic of obesity that is contributing to diabetes, cardiovascular disease and premature death. It has been known for many years that exercise can prevent diabetes and cardiovascular disease however the molecular events mediating this effect are not known. Recent associative evidence has suggested that a potential mediator of the beneficial effects of exercise may be the AMP-activated protein kinase signalling pathway. In the current study we intend to investigate the effects of exercise on fat metabolism in mice with deficient AMPK signalling to determine whether this is the critical enzyme responsible for the beneficial effects of exercise. A better understanding of the molecular mechanisms mediating the beneficial effects of exercise may lead to the design of new therapeutics for the treatment of diabetes and cardiovascular disease.

加拿大社会正在经历肥胖症的流行，肥胖症导致糖尿病、心血管疾病和过早死亡。多年来，运动可以预防糖尿病和心血管疾病已为人所知，但调节这一效应的分子事件尚不清楚。最近的相关证据表明，运动有益效果的一个潜在中介可能是AMP激活的蛋白激酶信号通路。在目前的研究中，我们打算研究运动对AMPK信号缺陷小鼠脂肪代谢的影响，以确定这是否是运动有益效果的关键酶。更好地了解运动有益效果的分子机制可能会导致设计治疗糖尿病和心血管疾病的新疗法。