Understanding the biological mechanisms involved in treatment free remission of chronic myeloid leukaemia

了解慢性粒细胞白血病无治疗缓解的生物学机制

• 批准号: nhmrc : GNT1138079
• 负责人: Dr Thao Nguyen
• 金额: $ 31.88万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-biological-mechanisms-myeloid-leukaemia/1348117
• 关键词: Understanding; biological; mechanisms; involved; treatment

Most patients with chronic myeloid leukaemia achieve excellent responses to therapy but need therapy for life. We have pioneered the concept that some patients can cease their therapy and not relapse (treatment free remission –TFR). By studying the immune system, the leukaemic stem cells and the bone marrow environment, we will determine why TFR is possible for some, but not all patients. This holds the key to improving the rate of TFR, thus moving the CML goal from disease control to cure.

大多数慢性粒细胞白血病患者对治疗有良好的反应，但需要终生治疗。我们首创了一些患者可以停止治疗并且不会复发（无治疗缓解 - TFR）的概念。通过研究免疫系统、白血病干细胞和骨髓环境，我们将确定为什么 TFR 对于某些而非所有患者是可能的。这是提高TFR率的关键，从而将CML目标从疾病控制转向治愈。